Chromosomal Instability: Mad2 beyond the Spindle Checkpoint
نویسندگان
چکیده
What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.
منابع مشابه
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ورودعنوان ژورنال:
- Current Biology
دوره 22 شماره
صفحات -
تاریخ انتشار 2012